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A local coupling model and compass parameter for eukaryotic chemotaxis
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 156839
Author(s) Arrieumerlou, Cécile; Meyer, Tobias
Author(s) at UniBasel Arrieumerlou, Cécile
Year 2005
Title A local coupling model and compass parameter for eukaryotic chemotaxis
Journal Developmental cell
Volume 8
Number 2
Pages / Article-Number 215-27
Keywords 1-Phosphatidylinositol 3-Kinase/physiology; Animals; Cells; Cultured; Chemotaxis/drug effects/immunology/*physiology; Complement C5a/administration & dosage/physiology; Computer Simulation; Dendritic Cells/drug effects/immunology/physiology; Eukaryotic Cells; Fibroblasts/drug effects/immunology/physiology; Humans; Mice; *Models; Biological; NIH 3T3 Cells; Phosphatidylinositol Phosphates/metabolism; Platelet-Derived Growth Factor/administration & Pseudopodia/drug effects/physiology; Signal Transduction; Stochastic Processes
Abstract Chemotaxis is a cellular sensing mechanism that guides immune cells to sites of infection and leads fibroblasts to sites of injury. Here, we show in migrating primary dendritic cells and fibroblasts that the leading edge is not a uniform signaling entity, but instead consists of independent coupling units in which transient activation of PI3-kinase links to local lamellipod extension and small discrete turns in the direction of migration. These findings led to a model in which global cell polarization is independent from the chemotaxis mechanism. In this model, chemotaxis does not require spatial integration but is instead a stochastic process in which each receptor binding event within the leading edge triggers a local lamellipod extension and a small turn in the direction of migration. We show that this model and a derived "compass parameter" are sufficient to simulate the observed random migration, biased random walk, and persistent chemotactic behaviors of eukaryotic cells.
Publisher Cell Press
ISSN/ISBN 1534-5807
edoc-URL http://edoc.unibas.ch/dok/A5259789
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.devcel.2004.12.007
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/15691763
ISI-Number WOS:000226875500012
Document type (ISI) Journal Article
 
   

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