Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 156590
Author(s) Hyman, C; Hofer, M; Barde, Y A; Juhasz, M; Yancopoulos, G D; Squinto, S P; Lindsay, R M
Author(s) at UniBasel Barde, Yves-Alain
Year 1991
Title BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
Journal Nature
Volume 350
Number 6315
Pages / Article-Number 230-2
Keywords Animals; Brain-Derived Neurotrophic Factor; Cells; Cultured; Dopamine/*metabolism; Immunohistochemistry; Nerve Growth Factors/*physiology; Nerve Tissue Proteins/*physiology; Neurons/*physiology; Rats; Substantia Nigra/*physiology
Abstract Brain-derived neurotrophic factor (BDNF), present in minute amounts in the adult central nervous system, is a member of the nerve growth factor (NGF) family, which includes neurotrophin-3 (NT-3). NGF, BDNF and NT-3 all support survival of subpopulations of neural crest-derived sensory neurons; most sympathetic neurons are responsive to NGF, but not to BDNF; NT-3 and BDNF, but not NGF, promote survival of sensory neurons of the nodose ganglion. BDNF, but not NGF, supports the survival of cultured retinal ganglion cells but both NGF and BDNF promote the survival of septal cholinergic neurons in vitro. However, knowledge of their precise physiological role in development and maintenance of the nervous system neurons is still limited. The BDNF gene is expressed in many regions of the adult CNS, including the striatum. A protein partially purified from bovine striatum, a target of nigral dopaminergic neurons, with characteristics apparently similar to those of BDNF, can enhance the survival of dopaminergic neurons in mesencephalic cultures. BDNF seems to be a trophic factor for mesencephalic dopaminergic neurons, increasing their survival, including that of neuronal cells which degenerate in Parkinson's disease. Here we report the effects of BDNF on the survival of dopaminergic neurons of the developing substantia nigra.
Publisher Macmillan
ISSN/ISBN 0028-0836
edoc-URL http://edoc.unibas.ch/dok/A5259556
Full Text on edoc No
Digital Object Identifier DOI 10.1038/350230a0
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/2005978
ISI-Number WOS:A1991FC77900057
Document type (ISI) Journal Article
 
   

MCSS v5.8 PRO. 0.320 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
28/03/2024