A novel 7-transmembrane receptor expressed in nerve growth factor-dependent sensory neurons
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 156549
Author(s) Friedel, R H; Stubbusch, J; Barde, Y A; Schnürch, H
Author(s) at UniBasel Barde, Yves-Alain
Year 2001
Title A novel 7-transmembrane receptor expressed in nerve growth factor-dependent sensory neurons
Journal Molecular and cellular neuroscience
Volume 17
Number 1
Pages / Article-Number 31-40
Keywords Animals; Blotting; Northern; Cells; Cultured; Central Nervous System/cytology/embryology/metabolism; Chick Embryo; Chickens; Cloning; Molecular; Enteric Nervous System/cytology/embryology/metabolism; Gene Expression Regulation; Developmental; In Situ Hybridization; Molecular Sequence Data; Nerve Growth Factor/*metabolism/pharmacology; Neurons; Afferent/cytology/drug effects/*metabolism; Organ Specificity/genetics; Peripheral Nervous System/cytology/embryology/metabolism; RNA; Messenger/biosynthesis; Receptors; Cell Surface/*biosynthesis/*genetics/metabolism; *Receptors; G-Protein-Coupled; Sequence Homology; Amino Acid; Species Specificity
Abstract This study reports on the full-length cDNA cloning of a gene identified on the basis of its preferential expression in nerve growth factor, compared with neurotrophin-3-dependent neurons. It encodes a putative 7-transmembrane polypeptide that is distantly related to other members of the G protein-coupled receptor superfamily. Unique features of this receptor include a very long carboxy-terminal tail of 360 amino acids and a specific expression pattern in the chick peripheral nervous system, including nerve growth factor-dependent sensory and sympathetic neurons, as well as enteric neurons. In the central nervous system, the receptor is strongly developmentally regulated and is expressed at high levels in the external granule cell layer of the cerebellum, as well as in motoneurons of the spinal cord, and in retinal ganglion cells.
Publisher Academic Press
ISSN/ISBN 1044-7431
edoc-URL http://edoc.unibas.ch/dok/A5259516
Full Text on edoc No
Digital Object Identifier DOI 10.1006/mcne.2000.0912
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/11161467
ISI-Number WOS:000166683900003
Document type (ISI) Journal Article
 
   

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