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Abietane Diterpenoids from Salvia sahendica - Antiprotozoal Activity and Determination of Their Absolute Configurations.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1563260
Author(s) Ebrahimi, Samad N; Zimmermann, Stefanie; Zaugg, Janine; Smiesko, Martin; Brun, Reto; Hamburger, Matthias
Author(s) at UniBasel Hamburger, Matthias
Smiesko, Martin
Ebrahimi, Samad
Zimmermann, Stefanie
Mateev, Matey
Brun, Reto
Year 2013
Title Abietane Diterpenoids from Salvia sahendica - Antiprotozoal Activity and Determination of Their Absolute Configurations.
Journal Planta medica
Volume 79
Number 2
Pages / Article-Number 150-6
Keywords Salvia sahendica, Lamiaceae, diterpenes, Plasmodium falciparum, Trypanosoma brucei rhodesiense
Abstract

In a screening of Iranian plants for antiprotozoal activity, an n-hexane extract of the roots of Salvia sahendica potently inhibited the growth of Plasmodium falciparum K1 strain. Subsequent HPLC-based activity profiling led to the identification of seven known and one new abietane-type diterpenoid. Structure elucidation was achieved by analysis of spectroscopic data including 1D and 2D NMR. The absolute configuration of sahandol (7) and sahandone (8) were assigned by comparison of experimental ECD spectra with calculated ECD data, using time-dependent density functional theory and methanol as the solvent. In vitro biological activity against P. falciparum and Trypanosoma brucei rhodesiense STIB 900 strain and cytotoxicity in rat myoblast (L6) cells were determined. The IC50 values of the compounds ranged from 0.8 然 to over 8.8 然 against P. falciparum, and from 1.8 然 to over 32.3 然 against T. brucei rhodesiense. The cytotoxic IC50 values ranged from 0.5-15.5 然. Selectivity indices for P. falciparum were 0.1 to 18.2, and 0.1 to 1.2 for T. brucei rhodesiense.

Publisher Hippokrates-Verl.
ISSN/ISBN 0032-0943
edoc-URL http://edoc.unibas.ch/dok/A6083661
Full Text on edoc No
Digital Object Identifier DOI 10.1055/s-0032-1328063
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/23299758
ISI-Number WOS:000313965100009
Document type (ISI) Journal Article
 
   

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