A simple adult-mouse test for tissue invasiveness in Yersinia enterocolitica strains of low experimental virulence
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 156285
Author(s) Bakour, R; Balligand, G; Laroche, Y; Cornelis, G; Wauters, G
Author(s) at UniBasel Cornelis, Guy R.
Year 1985
Title A simple adult-mouse test for tissue invasiveness in Yersinia enterocolitica strains of low experimental virulence
Journal The Journal of Medical Microbiology
Volume 19
Number 2
Pages / Article-Number 237-46
Keywords Animals; Antibodies; Bacterial/biosynthesis; Lymph Nodes/microbiology; Mice; Inbred Strains; Plasmids; Serotyping; Spleen/microbiology; Virulence; Yersinia Infections/immunology/microbiology; Yersinia enterocolitica/genetics/immunology/isolation & purification/*pathogenicity
Abstract The virulence of Yersinia enterocolitica depends on the presence of a 70-kilobase plasmid, called the Vwa plasmid. This situation is particularly favourable for studies of the mechanism of pathogenicity, but these are hindered by the lack of a suitable animal test to monitor the virulence of the human-pathogenic strains isolated outside the USA which belong to serogroups O:3, O:9 and O:5,27. We observed that, after oral administration to the mouse, the Vwa-positive strains of these serogroups produce a discrete systemic infection while the Vwa-negative strains do not. We present here a simple mouse-virulence test based on this observation.
Publisher Pathological Society of Great Britain and Ireland
ISSN/ISBN 0022-2615
edoc-URL http://edoc.unibas.ch/dok/A5259270
Full Text on edoc No
Digital Object Identifier DOI 10.1099/00222615-19-2-237
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/3981611
ISI-Number WOS:A1985AFG6900012
Document type (ISI) Journal Article
 
   

MCSS v5.8 PRO. 0.441 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
10/08/2020