A new class of proteins regulating gene expression in enterobacteria

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A new class of proteins regulating gene expression in enterobacteria

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	156241
Author(s)	Mikulskis, A V; Cornelis, G R
Author(s) at UniBasel	Cornelis, Guy R.
Year	1994
Title	A new class of proteins regulating gene expression in enterobacteria
Journal	Molecular microbiology
Volume	11
Number	1
Pages / Article-Number	77-86
Keywords	Amino Acid Sequence; Bacterial Proteins/genetics; Base Sequence; Chromosomes; Bacterial; Cloning; Molecular; Conjugation; Genetic; DNA Transposable Elements/genetics; DNA; Bacterial/isolation & purification; DNA-Binding Proteins; Enterobacteriaceae/genetics; Escherichia coli/genetics; Escherichia coli Proteins; Gene Expression Regulation; Bacterial/*genetics; Genes; Bacterial/genetics; Genetic Complementation Test; Molecular Sequence Data; Mutation; Recombinant Fusion Proteins/genetics; Transcription; Genetic/genetics; Yersinia enterocolitica/genetics
Abstract	YmoA and Hha are highly similar bacterial proteins downregulating gene expression in Yersinia enterocolitica and Escherichia coli, respectively. The phenotype of ymoA mutants evokes that of mutants affected in some histone-like proteins. This paper describes complementation of a ymoA mutation in Y. enterocolitica by the hha gene from E. coli. We show that YmoA and Hha are not only very similar proteins but that they are functionally interchangeable. Genetic experiments indicate that Hha can also stimulate transposition events in vivo. By Southern blot analysis we detected hha-homologous genes at least in Citrobacter diversus, Shigella flexneri, Shigella dysenteriae, Klebsiella pneumoniae and Salmonella typhimurium. We suggest that both YmoA and Hha belong to a new family of proteins downregulating gene expression in different enterobacteria.
Publisher	Blackwell
ISSN/ISBN	0950-382X
edoc-URL	http://edoc.unibas.ch/dok/A5259226
Full Text on edoc	No
Digital Object Identifier DOI	10.1111/j.1365-2958.1994.tb00291.x
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/8145648
ISI-Number	WOS:A1994MQ20600010
Document type (ISI)	Journal Article

25/04/2024

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