A new class of proteins regulating gene expression in enterobacteria
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 156241
Author(s) Mikulskis, A V; Cornelis, G R
Author(s) at UniBasel Cornelis, Guy R.
Year 1994
Title A new class of proteins regulating gene expression in enterobacteria
Journal Molecular microbiology
Volume 11
Number 1
Pages / Article-Number 77-86
Keywords Amino Acid Sequence; Bacterial Proteins/*genetics; Base Sequence; Chromosomes; Bacterial; Cloning; Molecular; Conjugation; Genetic; DNA Transposable Elements/genetics; DNA; Bacterial/isolation & purification; *DNA-Binding Proteins; Enterobacteriaceae/*genetics; Escherichia coli/genetics; *Escherichia coli Proteins; Gene Expression Regulation; Bacterial/*genetics; Genes; Bacterial/genetics; Genetic Complementation Test; Molecular Sequence Data; Mutation; Recombinant Fusion Proteins/genetics; Transcription; Genetic/genetics; Yersinia enterocolitica/genetics
Abstract YmoA and Hha are highly similar bacterial proteins downregulating gene expression in Yersinia enterocolitica and Escherichia coli, respectively. The phenotype of ymoA mutants evokes that of mutants affected in some histone-like proteins. This paper describes complementation of a ymoA mutation in Y. enterocolitica by the hha gene from E. coli. We show that YmoA and Hha are not only very similar proteins but that they are functionally interchangeable. Genetic experiments indicate that Hha can also stimulate transposition events in vivo. By Southern blot analysis we detected hha-homologous genes at least in Citrobacter diversus, Shigella flexneri, Shigella dysenteriae, Klebsiella pneumoniae and Salmonella typhimurium. We suggest that both YmoA and Hha belong to a new family of proteins downregulating gene expression in different enterobacteria.
Publisher Blackwell
ISSN/ISBN 0950-382X
edoc-URL http://edoc.unibas.ch/dok/A5259226
Full Text on edoc No
Digital Object Identifier DOI 10.1111/j.1365-2958.1994.tb00291.x
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/8145648
ISI-Number WOS:A1994MQ20600010
Document type (ISI) Journal Article
 
   

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