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Fine-mapping at the HTR2A locus reveals multiple episodic memory-related variants
Journal
Biological psychology
Volume
79
Number
2
Pages / Article-Number
239-42
Keywords
Serotonin, Polymorphism, Hippocampus, Imputation
Abstract
A functional polymorphism (His452Tyr) in the gene encoding the serotonin 2A receptor (HTR2A) has been previously associated with human episodic memory performance and with differences in brain volume in memory-related brain regions. Here we present data obtained through imputation and fine-mapping showing that multiple loci within HTR2A are significantly associated with human memory performance independently of the His452Tyr polymorphism. Our data support the existence of multiple memory-related loci within HTR2A.
