A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 156087
Author(s) Kramer, Ina; Sigrist, Markus; de Nooij, Joriene C; Taniuchi, Ichiro; Jessell, Thomas M; Arber, Silvia
Author(s) at UniBasel Arber, Silvia
Year 2006
Title A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification
Journal Neuron
Volume 49
Number 3
Pages / Article-Number 379-93
Keywords Animals; Basic Helix-Loop-Helix Transcription Factors/metabolism; Calcitonin Gene-Related Peptide/metabolism; Cell Count/methods; Ciliary Neurotrophic Factor/metabolism; Core Binding Factor Alpha 2 Subunit/genetics/*physiology; Core Binding Factor Alpha 3 Subunit/genetics/*physiology; Embryo; Mammalian; Ganglia; Spinal/*cytology; Gene Expression Regulation; Developmental/*physiology; Green Fluorescent Proteins/metabolism; Homeodomain Proteins/genetics/metabolism; Immunohistochemistry/methods; Mice; Transgenic; Models; Biological; Nerve Tissue Proteins/genetics/metabolism; Neurons; Afferent/classification/cytology/*metabolism; Receptor; trkB/metabolism; trkC/genetics; Signal Transduction/genetics/*physiology; Substance P/metabolism; Transcription Factors/metabolism; tau Proteins/genetics
Abstract Subpopulations of sensory neurons in the dorsal root ganglion (DRG) can be characterized on the basis of sensory modalities that convey distinct peripheral stimuli, but the molecular mechanisms that underlie sensory neuronal diversification remain unclear. Here, we have used genetic manipulations in the mouse embryo to examine how Runx transcription factor signaling controls the acquisition of distinct DRG neuronal subtype identities. Runx3 acts to diversify an Ngn1-independent neuronal cohort by promoting the differentiation of proprioceptive sensory neurons through erosion of TrkB expression in prospective TrkC+ sensory neurons. In contrast, Runx1 controls neuronal diversification within Ngn1-dependent TrkA+ neurons by repression of neuropeptide CGRP expression and controlling the fine pattern of laminar termination in the dorsal spinal cord. Together, our findings suggest that Runx transcription factor signaling plays a key role in sensory neuron diversification.
Publisher Cell Press
ISSN/ISBN 0896-6273
edoc-URL http://edoc.unibas.ch/dok/A5259074
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.neuron.2006.01.008
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/16446142
ISI-Number WOS:000235260900010
Document type (ISI) Journal Article

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