Assembly of motor circuits in the spinal cord : driven to function by genetic and experience-dependent mechanisms
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 156081
Author(s) Ladle, David R; Pecho-Vrieseling, Eline; Arber, Silvia
Author(s) at UniBasel Arber, Silvia
Pecho-Vrieseling, Eline
Year 2007
Title Assembly of motor circuits in the spinal cord : driven to function by genetic and experience-dependent mechanisms
Journal Neuron
Volume 56
Number 2
Pages / Article-Number 270-83
Keywords Animals; Efferent Pathways/*physiology; Gene Expression; Models; Biological; Motor Neurons/*physiology; Receptors; Nerve Growth Factor/genetics/*physiology
Abstract

Motor circuits in the spinal cord integrate information from various sensory and descending pathways to control appropriate motor behavior. Recent work has revealed that target-derived retrograde signaling mechanisms act to influence sequential assembly of motor circuits through combinatorial action of genetic and experience-driven programs. These parallel activities imprint somatotopic information at the level of the spinal cord in precisely interconnected circuits and equip animals with motor circuits capable of reacting to changing demands throughout life.

Publisher Cell Press
ISSN/ISBN 0896-6273
edoc-URL http://edoc.unibas.ch/dok/A5259069
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.neuron.2007.09.026
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/17964245
ISI-Number WOS:000250740700006
Document type (ISI) Journal Article, Review
 
   

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