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Bartonella-host-cell interactions and vascular tumour formation
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 156012
Author(s) Dehio, C.
Author(s) at UniBasel Dehio, Christoph
Year 2005
Title Bartonella-host-cell interactions and vascular tumour formation
Journal Nature Reviews Microbiology
Volume 3
Number 8
Pages / Article-Number 621-31
Keywords Bacteremia/microbiology; Bartonella/genetics/*pathogenicity; Bartonella Infections/*microbiology; Erythrocytes/microbiology; Humans; Neovascularization; Pathologic/*microbiology; Vascular Neoplasms/*microbiology; Virulence/genetics
Abstract Bartonellae are arthropod-borne bacterial pathogens that typically cause persistent infection of erythrocytes and endothelial cells in their mammalian hosts. In human infection, these host-cell interactions result in a broad range of clinical manifestations. Most remarkably, bartonellae can trigger massive proliferation of endothelial cells, leading to vascular tumour formation. The recent availability of infection models and bacterial molecular genetic techniques has fostered research on the pathogenesis of the bartonellae and has advanced our understanding of the virulence mechanisms that underlie the host-cell tropism, the subversion of host-cell functions during bacterial persistence, as well as the formation of vascular tumours by these intriguing pathogens.
Publisher Nature Publishing Group
ISSN/ISBN 1740-1526 ; 1740-1534
edoc-URL http://edoc.unibas.ch/dok/A5259004
Full Text on edoc No
Digital Object Identifier DOI 10.1038/nrmicro1209
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/16064054
ISI-Number WOS:000230879700013
Document type (ISI) Journal Article, Review
 
   

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