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Absence of reflex sympathetic activation by the selective renal vasodilator CGP 22979A in the conscious rat
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 155628
Author(s) Criscione, L; Cave, A; Burdet, R; Hofbauer, K G
Author(s) at UniBasel Hofbauer, Karl G.
Year 1987
Title Absence of reflex sympathetic activation by the selective renal vasodilator CGP 22979A in the conscious rat
Journal Clinical and Experimental Hypertension. Part A, Theory and Practice
Volume 9 Suppl 1
Pages / Article-Number 319-26
Keywords Animals; Blood Pressure/drug effects; Consciousness; Heart Rate/drug effects; Hydrazines/*pharmacology; Male; Rats; Inbred Strains; Reflex/*drug effects; Renal Circulation/*drug effects; Splanchnic Nerves/drug effects; Sympathetic Nervous System/*drug effects; Vasodilator Agents/*pharmacology
Abstract The effects of the selective renal vasodilator prodrug CGP 22979A on mean arterial blood pressure (MAP), heart rate (HR) and sympathetic efferent splanchnic nerve activity (SpNA) were investigated in conscious normotensive rats, and compared with those of the active drug CGP 18137A, a hydrallazine-like systemic vasodilator. CGP 18137A (0.03 to 1mg/kg i.v.) produced a dose-dependent decrease in MAP, whereas HR and SpNA increased. CGP 22979A affected neither BP nor HR and SpNA at doses of 1 and 3mg/kg i.v. which induce a selective increase in renal blood flow. In contrast, a dose of 30mg/kg i.v., which produced systemic effects comparable to those of CGP 18137A, stimulated SpNA to the same extent as 18137A did. These results demonstrate that the rise in renal blood flow induced by low doses of CGP 22979A is not associated with an increase in efferent sympathetic nerve activity. They suggest also that selective renal vasodilatation can be accomplished without an activation of the sympathetic nervous system.
Publisher Marcel Dekker
ISSN/ISBN 0730-0077
edoc-URL http://edoc.unibas.ch/dok/A5258639
Full Text on edoc No
Digital Object Identifier DOI 10.3109/10641968709160182
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/3677458
ISI-Number WOS:A1987L004900024
Document type (ISI) Article
 
   

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