Agrin orchestrates synaptic differentiation at the vertebrate neuromuscular junction
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 155386
Author(s) Ruegg, M. A.; Bixby, J. L.
Author(s) at UniBasel Rüegg, Markus A.
Year 1998
Title Agrin orchestrates synaptic differentiation at the vertebrate neuromuscular junction
Journal Trends in Neurosciences
Volume 21
Number 1
Pages / Article-Number 22-7
Keywords Agrin/metabolism/*physiology; Animals; Cell Differentiation/*physiology; Humans; Neuromuscular Junction/metabolism/*physiology; Neurons/*physiology; Synapses/metabolism/*physiology
Mesh terms Agrin, physiology; Animals; Cell Differentiation, physiology; Humans; Neuromuscular Junction, physiology; Neurons, physiology; Synapses, physiology
Abstract The synapse is a key structure that is involved in perception, learning and memory. Understanding the sequence of steps that is involved in establishing synapses during development might also help to understand mechanisms that cause changes in synapses during learning and memory. For practical reasons, most of our current knowledge of synapse development is derived from studies of the vertebrate neuromuscular junction (NMJ). Several lines of evidence strongly suggest that motor axons release the molecule agrin to induce the formation of the postsynaptic apparatus in muscle fibers. Recent advances implicate proteins such as dystroglycan, MuSK, and rapsyn in the transduction of agrin signals. Recently, additional functions of agrin have been discovered, including the upregulation of gene transcription in myonuclei and the control of presynaptic differentiation. Agrin therefore appears to play a unique role in controlling synaptic differentiation on both sides of the NMJ.
Publisher Elsevier
ISSN/ISBN 0166-2236 ; 1878-108X
edoc-URL http://edoc.unibas.ch/dok/A5258420
Full Text on edoc Restricted
Digital Object Identifier DOI 10.1016/S0166-2236(97)01154-5
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/9464682
ISI-Number WOS:000071305400009
Document type (ISI) Journal Article, Review
 
   

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