Active transport of proteins into the nucleus
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 153824
Author(s) Wagner, P.; Kunz, J.; Koller, A.; Hall, M. N.
Author(s) at UniBasel Hall, Michael N.
Year 1990
Title Active transport of proteins into the nucleus
Journal FEBS Letters
Volume 275
Number 1-2
Pages / Article-Number 1-5
Keywords Amino Acid Sequence; Animals; Biological Transport; Active; Cell Compartmentation; Molecular Sequence Data; Nuclear Envelope/*metabolism/ultrastructure; Nuclear Proteins/chemistry/*metabolism; Receptors; Cell Surface/metabolism; Regulatory Sequences; Nucleic Acid

Nuclear proteins are actively and posttranslationally transported across the nuclear envelope. This transport is a highly selective process that can be divided into two steps, receptor-binding followed by translocation through the nuclear envelope. Receptor-binding is mediated by nuclear localization signals that have been identified in many nuclear proteins. Translocation is energy-dependent and occurs through the nuclear pore complex.

Publisher Elsevier
ISSN/ISBN 0014-5793 ; 1873-3468
Full Text on edoc No
Digital Object Identifier DOI 10.1016/0014-5793(90)81425-N
PubMed ID
ISI-Number WOS:A1990EL45000001
Document type (ISI) Journal Article, Review

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