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Growth and aging: a common molecular mechanism
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 153739
Author(s) Blagosklonny, M. V.; Hall, M. N.
Author(s) at UniBasel Hall, Michael N.
Year 2009
Title Growth and aging: a common molecular mechanism
Journal Aging
Volume 1
Number 4
Pages / Article-Number 357-362
Keywords aging, growth, rapamycin, TOR, mitochondria
Abstract

It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.

Publisher Impact Journals
ISSN/ISBN 1945-4589
edoc-URL http://edoc.unibas.ch/dok/A5258121
Full Text on edoc No
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20157523
ISI-Number WOS:000276401100003
Document type (ISI) Journal Article, Review
 
   

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02/05/2024