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Apoptosis in HIV-infected individuals is an early marker occurring independently of high viremia
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 153489
Author(s) Rothen, M; Gratzl, S; Hirsch, H H; Moroni, C
Author(s) at UniBasel Moroni, Christoph
Year 1997
Title Apoptosis in HIV-infected individuals is an early marker occurring independently of high viremia
Journal AIDS Research and Human Retroviruses
Volume 13
Number 9
Pages / Article-Number 771-9
Keywords *Apoptosis; Biological Markers; CD4 Lymphocyte Count; Cells; Cultured; Disease Progression; Flow Cytometry; HIV Infections/immunology/*physiopathology; HIV Seropositivity/immunology/*physiopathology; HIV-1/*isolation & purification; Humans; Lymphocyte Activation; Lymphocytes/pathology/*physiology; Polymerase Chain Reaction; RNA; Viral/analysis; Regression Analysis; Viremia/*diagnosis/immunology
Abstract We have analyzed the immunoreactivity of peripheral blood mononuclear cells by determining the proliferative response to four mitogens, one superantigen, and one recall antigen together with the occurrence of activation-induced apoptosis from 213 HIV-1-seropositive individuals from all stages of infection. The expected decline of immunoreactivity observed with time after infection correlated with disease progression and the loss of CD4 cells. Apoptosis was already detectable at the early stages of infection and increased only slightly with disease progression. In analyzing 13 patients with high and low apoptosis rates we observed no correlation to HIV-1 viremia. Our results argue that mitogen-induced apoptosis occurs in both infected and noninfected T cells and can be detected before mitogenic responsiveness is reduced.
Publisher Mary Ann Liebert
ISSN/ISBN 0889-2229
edoc-URL http://edoc.unibas.ch/dok/A5257891
Full Text on edoc No
Digital Object Identifier DOI 10.1089/aid.1997.13.771
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/9171221
ISI-Number WOS:A1997XC32400006
Document type (ISI) Article
 
   

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