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Atomic force microscopy : a powerful tool to observe biomolecules at work
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 153266
Author(s) Engel, A; Lyubchenko, Y; Müller, D
Author(s) at UniBasel Engel, Andreas
Year 1999
Title Atomic force microscopy : a powerful tool to observe biomolecules at work
Journal Trends in cell biology
Volume 9
Number 2
Pages / Article-Number 77-80
Keywords Microscopy; Atomic Force/*methods; Nucleic Acid Conformation
Abstract Atomic force microscopes (AFMs) move a sharp tip attached to a soft cantilever in a TV-raster-like pattern over a surface and record deflections of the tip that correspond to the surface topography. When operated in physiological solutions, an AFM allows biomolecules to be observed in their native environment. Progress in instrumentation, sample-preparation methods and recording conditions has provided images of biomolecules and their assemblies that reveal submolecular details. In addition, the AFM allows conformational changes to be observed directly. This article discusses these points and illustrates them with some pertinent examples.
Publisher Elsevier
ISSN/ISBN 0962-8924
edoc-URL http://edoc.unibas.ch/dok/A5257679
Full Text on edoc No
Digital Object Identifier DOI 10.1016/S0962-8924(98)01415-9
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/10087624
ISI-Number WOS:000079416700010
Document type (ISI) Journal Article, Review
 
   

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