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Analysis of glycogen storage disease by in vivo 13C NMR : comparison of normal volunteers with a patient
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 153049
Author(s) Beckmann, N.; Seelig, J.; Wick, H.
Author(s) at UniBasel Seelig, Joachim
Year 1990
Title Analysis of glycogen storage disease by in vivo 13C NMR : comparison of normal volunteers with a patient
Journal Magnetic Resonance in Medicine
Volume 16
Number 1
Pages / Article-Number 150-60
Keywords Abdominal Muscles/chemistry; Adipose Tissue/chemistry; Adult; Carbon; Dietary Carbohydrates/pharmacology; Dietary Proteins/pharmacology; Glycogen/*analysis; Glycogen Storage Disease Type III/*metabolism; Head; Humans; Leg; Liver/chemistry; Magnetic Resonance Spectroscopy/*diagnostic use/methods; Male; Muscles/*chemistry
Abstract Broadband proton-decoupled natural abundance 13C spectra of the human calf, liver, and head were obtained from normal volunteers and a patient with glycogen type IIIA storage disease. Two concentric and coplanar surface coils of diameters 8.0 cm and 13.0 cm were used for 13C (at 16.0 MHz) and 1H (at 63.6 MHz), respectively. A WALTZ-8 sequence lead to homogeneous decoupling over a large volume. In addition to lipid resonances a variety of other metabolite resonances could be resolved. The glycogen concentration in the muscle and the liver of normal volunteers varied considerably depending on dietary preparation and physical exercise. The glycogen level in the liver and the calf of a patient with glycogen type IIIA storage disease was increased by a factor of 2-3 compared to normal, well-trained volunteers. Proton-decoupled 13C spectra of human head are reported for the first time. The spectra are dominated by lipid resonances but an additional resonance at 54.0 ppm is clearly visible. The proton-decoupled 13C head spectrum of a patient with glycogen type IIIA storage disease revealed additional resonances between 71.0 and 85.0 ppm.
Publisher Wiley-Liss
ISSN/ISBN 0740-3194 ; 1522-2594
edoc-URL http://edoc.unibas.ch/dok/A5257469
Full Text on edoc No
Digital Object Identifier DOI 10.1002/mrm.1910160114
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/2147732
ISI-Number WOS:A1990EF62300013
Document type (ISI) Journal Article
 
   

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