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Aluminum-27 nuclear magnetic resonance spectroscopy and imaging of the human gastric lumen
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 153017
Author(s) Kaspar, A.; Bilecen, D.; Scheffler, K.; Seelig, J.
Author(s) at UniBasel Seelig, Joachim
Year 1996
Title Aluminum-27 nuclear magnetic resonance spectroscopy and imaging of the human gastric lumen
Journal Magnetic Resonance in Medicine
Volume 36
Number 2
Pages / Article-Number 177-82
Keywords aluminum NMR spectroscopy, aluminum NMR imaging, human stomach imaging
Abstract Aluminum NMR is proposed as a new imaging and spectroscopy modality. Its potential is exemplified by in vivo studies of the human stomach. The dissolution kinetics of aluminum-containing drugs at physiological doses and their removal from the human stomach have been followed by 27Al magnetic resonance spectroscopy (MRS). Aluminum concentrations as low as 0.5 mg Al3+ in the human stomach can be detected. The time course of gastric emptying has been visualized with 27Al magnetic resonance imaging (MRI) under normal conditions and in the presence of an antimuscarinic agent, which reduces the gastric motor function. 27Al MRI is the only direct method to visualize the gastric pH. 27Al MRI opens new possibilities for medical and pharmaceutical science.
Publisher Wiley-Liss
ISSN/ISBN 0740-3194 ; 1522-2594
edoc-URL http://edoc.unibas.ch/dok/A5257438
Full Text on edoc No
Digital Object Identifier DOI 10.1002/mrm.1910360202
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/8843369
ISI-Number WOS:A1996VA98400001
Document type (ISI) Journal Article
 
   

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