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Allelic variants of dopamine receptor D4 (DRD4) and serotonin receptor 5HT2c (HTR2c) and temperament factors : replication tests
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 149609
Author(s) Kühn, K U; Meyer, K; Nöthen, M M; Gänsicke, M; Papassotiropoulos, A; Maier, W
Author(s) at UniBasel Papassotiropoulos, Andreas
Year 1999
Title Allelic variants of dopamine receptor D4 (DRD4) and serotonin receptor 5HT2c (HTR2c) and temperament factors : replication tests
Journal American journal of medical genetics
Volume 88
Number 2
Pages / Article-Number 168-72
Abstract

The contribution of genetic factors to personality differences between individuals is evidenced by twin and adoption studies. Ebstein et al. [1996, 1997a, 1997b] reported an association between the long repeat allele of the dopamine D4-exon-III receptor polymorphism and the human personality dimension novelty seeking (NS), between the 5HT2c-ser-23 allele and reward dependence, and an interaction between both receptor polymorphisms and reward dependence. Subsequent replication tests mainly reported controversial results for the association between DRD4-exon-III long repeat and NS. We examined a homogeneous study population of 190 healthy male students of middle European descent, aged between 20 and 30 years using Cloninger's TPQ in order to replicate Ebstein's findings. Using a significance level of 1%, no association between the long repeat of the DRD4-exon-III polymorphism and NS and between the 5HT2c receptor polymorphism and reward dependence was found, but a significant interaction effect of DRD4 and 5HT2c receptor polymorphisms on reward dependence was observed in accordance to Ebstein's report.

Publisher Wiley-Liss
ISSN/ISBN 0148-7299
edoc-URL http://edoc.unibas.ch/dok/A5257231
Full Text on edoc No
Digital Object Identifier DOI 10.1002/(SICI)1096-8628(19990416)88:2<168::AID-AJMG14>3.0.CO;2-P
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/10206238
Document type (ISI) Journal Article
 
   

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