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Common Kibra alleles are associated with human memory performance
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
149539
Author(s)
Papassotiropoulos, Andreas; Stephan, Dietrich A.; Huentelman, Matthew J.; Hoerndli, Frederic J.; Craig, David W.; Pearson, John V.; Huynh, Kim-Dung; Brunner, Fabienne; Corneveaux, Jason; Osborne, David; Wollmer, M. Axel; Aerni, Amanda; Coluccia, Daniel; Hänggi, Jürgen; Mondadori, Christian R. A.; Buchmann, Andreas; Reiman, Eric M.; Caselli, Richard J.; Henke, Katharina; de Quervain, Dominique J.-F.
Common Kibra alleles are associated with human memory performance
Journal
Science
Volume
314
Number
5798
Pages / Article-Number
475-8
Abstract
Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.
Publisher
American Association for the Advancement of Science
