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Endocrine toxicity: interference of xenobiotics with steroid homeostasis
| Third-party funded project |
| Project title |
Endocrine toxicity: interference of xenobiotics with steroid homeostasis |
| Principal Investigator(s) |
Odermatt, Alex
|
| Co-Investigator(s) |
Rudaz, Serge
|
| Project Members |
Engeli, Roger
Strajhar, Petra
Beck, Katharina
|
| Organisation / Research unit |
Departement Pharmazeutische Wissenschaften / Molecular and Systems Toxicology (Odermatt) |
| Project Website |
http://www.scaht.org/scaht/en/ |
| Project start |
01.01.2013 |
| Probable end |
31.12.2016 |
| Status |
Completed |
| Abstract |
The project investigates the interference of xenobiotics with corticosteroid and sex steroid hormone homeostasis. The impact of xenobiotics on nuclear steroid hormone receptors and downstream signaling is investigated. Suitable screening tools may help to identify xenobiotics interfering with receptor function. In addition, the impact of xenobiotics on steroid hormone metabolising enzymes is studied. The goal of the project is to provide knowledge and tools aiding the identification and characterization of xenobotics interfering with corticosteroid and androgen action. |
| Keywords |
steroid, endocrine disruption |
| Financed by |
Swiss Government (Research Cooperations)
|
Published results () |
| |
ID |
Autor(en) |
Titel |
ISSN / ISBN |
Erschienen in |
Art der Publikation |
|
1519861 |
Nashev, Lyubomir G.; Vuorinen, Anna; Praxmarer, Lukas; Chantong, Boonrat; Cereghetti, Diego; Winiger, Rahel; Schuster, Daniela; Odermatt, Alex |
Virtual screening as a strategy for the identification of xenobiotics disrupting corticosteroid action |
1932-6203 |
PLoS ONE |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
|
1519894 |
Meyer, Arne; Strajhar, Petra; Murer, Céline; Da Cunha, Thierry; Odermatt, Alex |
Species-specific differences in the inhibition of human and zebrafish 11β-hydroxysteroid dehydrogenase 2 by thiram and organotins |
0300-483X |
Toxicology |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
|
1519896 |
Fürstenberger, Cornelia; Vuorinen, Anna; Da Cunha, Thierry; Kratschmar, Denise V; Saugy, Martial; Schuster, Daniela; Odermatt, Alex |
The anabolic androgenic steroid fluoxymesterone inhibits 11β-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation. |
1096-6080 |
Toxicological sciences |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
|
2237793 |
Vuorinen, Anna; Odermatt, Alex; Schuster, Daniela |
In silico methods in the discovery of endocrine disrupting chemicals |
0960-0760 ; 1879-1220 |
Journal of Steroid Biochemistry and Molecular Biology |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
|
2237809 |
Meyer, Arne; Vuorinen, Anna; Zielinska, Agnieszka E; Strajhar, Petra; Lavery, Gareth G; Schuster, Daniela; Odermatt, Alex |
Formation of threohydrobupropion from bupropion is dependent on 11β-hydroxysteroid dehydrogenase 1 |
1521-009X |
Drug metabolism and disposition |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
|
2237812 |
Meyer, Arne; Vuorinen, Anna; Zielinska, Agnieszka E; Da Cunha, Thierry; Strajhar, Petra; Lavery, Gareth G; Schuster, Daniela; Odermatt, Alex |
Carbonyl reduction of triadimefon by human and rodent 11β-hydroxysteroid dehydrogenase 1 |
0006-2952 |
Biochemical pharmacology |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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Cooperations () |
| |
ID |
Kreditinhaber |
Kooperationspartner |
Institution |
Laufzeit - von |
Laufzeit - bis |
|
1558431 |
Odermatt, Alex |
Terracciano, Luigi |
University Hospital Basel |
01.01.2012 |
31.12.2016 |
|
100440 |
Odermatt, Alex |
Krähenbühl, Stephan, Head Clinical Pharmacology and Toxicology |
Universtiy of Basel |
01.01.2009 |
31.12.2014 |
|
2356674 |
Odermatt, Alex |
Rudaz, Serge |
University of Geneva |
01.01.2013 |
31.12.2018 |
|
2356675 |
Odermatt, Alex |
Tschudi-Monnet, Florianne |
University of Lausanne |
01.01.2013 |
31.12.2017 |
|
100815 |
Odermatt, Alex |
Schuster, Daniela, Scientist |
Pharmazeutische Chemie, Institut für Pharmazie, Universität Innsbruck |
01.04.2008 |
31.12.2014 |
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