Aging and osteoarthritis: an inevitable encounter?
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1470247
Author(s) Hügle, Thomas; Geurts, Jeroen; Nüesch, Corina; Müller-Gerbl, Magdalena; Valderrabano, Victor
Author(s) at UniBasel Hügle, Thomas
Valderrabano, Victor
Müller-Gerbl, Magdalena
Geurts, Jeroen
Year 2012
Title Aging and osteoarthritis: an inevitable encounter?
Journal Journal of aging research
Volume 2012
Pages / Article-Number 950192
Abstract

Osteoarthritis (OA) is a major health burden of our time. Age is the most prominent risk factor for the development and progression of OA. The mechanistic influence of aging on OA has different facets. On a molecular level, matrix proteins such as collagen or proteoglycans are modified, which alters cartilage function. Collagen cross-linking within the bone results in impaired plasticity and increased stiffness. Synovial or fat tissue, menisci but also ligaments and muscles play an important role in the pathogenesis of OA. In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint. Inflammation in form of cellular infiltration of synovial tissue or subchondral bone and expression of inflammatory cytokines is more and more recognized as trigger of OA. It has been demonstrated that joint movement can exhibit anti-inflammatory mechanisms. Therefore physical activity or physiotherapy in the elderly should be encouraged, also in order to increase the muscle mass. A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system. New treatment strategies, for example with mesenchymal stem cells (MSC) are investigated, despite clear evidence for their efficacy is lacking.

Publisher Hindawi Publishing Corporation
ISSN/ISBN 2090-2212
URL http://www.hindawi.com/journals/jar/2012/950192/
edoc-URL http://edoc.unibas.ch/dok/A6056160
Full Text on edoc No
Digital Object Identifier DOI 10.1155/2012/950192
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/22720159
ISI-Number MEDLINE:22720159
Document type (ISI) Journal Article
 
   

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