Tomography of microvascular structures in murine brain tumors
Third-party funded project
Project title Tomography of microvascular structures in murine brain tumors
Principal Investigator(s) Müller, Bert
Co-Investigator(s) Hieber, Simone
Organisation / Research unit Departement Biomedical Engineering / Biomaterials Science Center (Müller),
Departement Zahnmedizin / Werkstoffwissenschaft (Müller)
Project start 01.01.2013
Probable end 30.11.2016
Status Completed

The three-dimensional vascular structures down to the smallest capillaries have been of vital interest in cancer research because of the demand for alternatives to the established treatments (surgery, medication and radiation). The present research efforts range from in vivo imaging (MRI, US, and PET), via post mortem methods, including micro computed computer tomography. In a previous study, we showed that synchrotron radiation-based necessary spatial resolution and contrast to capture the smallest vessels from casts. Tumors with damaged vessel walls are inappropriate for casting. Therefore, phase tomography was applied to visualize the capillaries. Grating-based tomography yields the necessary contrast but vessels with a diameter smaller than 20 provides the necessary spatial resolution but hardly enough contrast. Consequently, we propose first to improve the spatial resolution of grating-based tomography, second to identify rather simple in-line tomography approaches such as the one introduced by Paganin searching for better contrast, and third to combine tomograms from both approaches to gain additional information toward the smallest capillaries.


Keywords phase contrast tomography, vascular tree , tumour growth, segmentation, blood vessel diameter, synchrotron radiation
Financed by Swiss National Science Foundation (SNSF)

MCSS v5.8 PRO. 0.400 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |