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Biomarkers for mechanically Ventilated patients (BioVENT)
| Third-party funded project |
| Project title |
Biomarkers for mechanically Ventilated patients (BioVENT) |
| Principal Investigator(s) |
Stolz, Daiana
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| Organisation / Research unit |
Bereich Medizinische Fächer (Klinik) / Pneumologie (Stolz) |
| Project start |
01.01.2011 |
| Probable end |
31.12.2013 |
| Status |
Completed |
| Abstract |
Background: The introduction of a risk-adjusted approach in intensive care is expected to individualize therapeutic measures, thereby minimizing adverse events and costs.
Objectives: To identify the individual predictive strength of clinical and laboratorial parameters for prognostication in patients requiring mechanical ventilation.
Setting: 1000 mechanically ventilated patients will be considered for study inclusion in 3 University Hospitals in Switzerland and France.
Methods: Assessments, including vital parameters, ventilator settings, laboratory values and clinical ICU scores (SAPS II, SOFA) will be performed at the start of mechanical ventilation and after 48 and 96 hours. Blood sampling for the determination of circulating biomarkers will be drawn. Attending physicians will be requested to estimate the probability of patients? survival. The clinical course of the disease will be appraised daily within 28 days of inclusion. The sub-groups of patients developing ventilator-associated pneumonia or requiring prolonged mechanical ventilation will be additionally evaluated at pneumonia onset and after 21 days. The predictors for successful extubation will be investigated in patients fulfilling standard criteria for weaning from mechanical ventilation at beginning of weaning process, 24 and 48 hours after extubation.
End-points: The primary endpoint is 28-day survival. Secondary endpoints include long-term survival, length of hospital and ICU stay, and weaning outcome.
Expected benefit: This study will provide a useful tool for daily prognostication at the bedside and potentially the basis for future interventional trials. |
| Financed by |
Foundations and Associations
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05/05/2024
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