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NCCR MSE - Molecular Factories Based on Artificial Metalloenzymes
Third-party funded project |
Project title |
NCCR MSE - Molecular Factories Based on Artificial Metalloenzymes |
Principal Investigator(s) |
Ward, Thomas R.
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Project Members |
Heinisch, Tillmann Okamoto, Yasunori
|
Organisation / Research unit |
Departement Chemie / Bioanorganische Chemie (Ward) |
Project Website |
http://www.nccr-mse.ch/en/no_cache/research/projects-detail/project/molecular-factories-based-on-artificial-metalloenzymes/ |
Project start |
01.07.2014 |
Probable end |
30.06.2018 |
Status |
Completed |
Abstract |
Artificial metalloenzymes (ArMs) result from the incorporation of abiotic cofactors within a host protein. In collaboration with various groups of the NCCR, we aim at engineering metabolic pathways incorporating ArMs. The challenges addressed during this funding period include: i) successful compartmentalization and evolution of ArMs within the periplasm of E coli, ii) engineering enzyme cascades with ArMs and iii) cross-regulation of ArMs. |
Keywords |
Artificial metalloenzymes, ArMs, enzyme cascades |
Financed by |
Swiss National Science Foundation (SNSF)
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Published results () |
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ID |
Autor(en) |
Titel |
ISSN / ISBN |
Erschienen in |
Art der Publikation |
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3350388 |
Quinto, Tommaso; Köhler, Valentin; Häussinger, Daniel; Ward, Thomas R. |
Artificial metalloenzymes for the diastereoselective reduction of NAD+ to NAD2H |
1477-0520 ; 1477-0539 |
Organic and Biomolecular Chemistry |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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3350378 |
Zhao, J.; Kajetanowicz, A.; Ward, T.R. |
Carbonic anhydrase II as host protein for the creation of a biocompatible artificial metathesase |
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Org. Biomol. Chem. |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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3350370 |
Heinisch, Tillmann; Ward, Thomas R. |
Latest Developments in Metalloenzyme Design and Repurposing |
1434-1948 ; 1099-0682 |
European Journal of Inorganic Chemistry |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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3350368 |
Reuter, Raphael; Ward, Thomas R. |
Profluorescent substrates for the screening of olefin metathesis catalysts |
1860-5397 |
Beilstein journal of organic chemistry |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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3350364 |
Heinisch, Tillmann; Pellizzoni, Michaela; Dürrenberger, Marc; Tinberg, Christine E.; Köhler, Valentin; Häussinger, Daniel; Klehr, Juliane; Baker, David; Ward, Thomas R. |
Improving the catalytic performance of an artificial metalloenzyme by computational design |
0002-7863 |
Journal of the American Chemical Society |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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28/03/2024
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