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NCCR MSE - Molecular Factories Based on Artificial Metalloenzymes
Third-party funded project
Project title NCCR MSE - Molecular Factories Based on Artificial Metalloenzymes
Principal Investigator(s) Ward, Thomas R.
Project Members Heinisch, Tillmann
Okamoto, Yasunori
Organisation / Research unit Departement Chemie / Bioanorganische Chemie (Ward)
Project Website http://www.nccr-mse.ch/en/no_cache/research/projects-detail/project/molecular-factories-based-on-artificial-metalloenzymes/
Project start 01.07.2014
Probable end 30.06.2018
Status Completed
Abstract

Artificial metalloenzymes (ArMs) result from the incorporation of abiotic cofactors within a host protein. In collaboration with various groups of the NCCR, we aim at engineering metabolic pathways incorporating ArMs. The challenges addressed during this funding period include: i) successful compartmentalization and evolution of ArMs within the periplasm of E coli, ii) engineering enzyme cascades with ArMs and iii) cross-regulation of ArMs.

Keywords Artificial metalloenzymes, ArMs, enzyme cascades
Financed by Swiss National Science Foundation (SNSF)

Published results ()

  ID Autor(en) Titel ISSN / ISBN Erschienen in Art der Publikation
3350388  Quinto, Tommaso; Köhler, Valentin; Häussinger, Daniel; Ward, Thomas R.  Artificial metalloenzymes for the diastereoselective reduction of NAD+ to NAD2H  1477-0520 ; 1477-0539  Organic and Biomolecular Chemistry  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
3350378  Zhao, J.; Kajetanowicz, A.; Ward, T.R.  Carbonic anhydrase II as host protein for the creation of a biocompatible artificial metathesase    Org. Biomol. Chem.  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
3350370  Heinisch, Tillmann; Ward, Thomas R.  Latest Developments in Metalloenzyme Design and Repurposing  1434-1948 ; 1099-0682  European Journal of Inorganic Chemistry  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
3350368  Reuter, Raphael; Ward, Thomas R.  Profluorescent substrates for the screening of olefin metathesis catalysts  1860-5397  Beilstein journal of organic chemistry  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
3350364  Heinisch, Tillmann; Pellizzoni, Michaela; Dürrenberger, Marc; Tinberg, Christine E.; Köhler, Valentin; Häussinger, Daniel; Klehr, Juliane; Baker, David; Ward, Thomas R.  Improving the catalytic performance of an artificial metalloenzyme by computational design  0002-7863  Journal of the American Chemical Society  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
   

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