Ionic gradients and biomarkers play a crucial role in molecular factories for establishing, maintaining and controlling the targeted functionality. To monitor these biomarkers, miniaturized sensing devices with dimensions smaller than the molecular factory volume shall provide valuable information about its  dynamical behavior. Ion-sensitive field-effect tran­sistors (ISFETs) based on silicon nanoribbon tran­sistors (SiNRs) are a very promising platform to measure local concentrations of ions such as protons (pH), sodium, potassium or calcium ions or even small biomarkers relevant to a large variety of bio­logical processes. Here, the SiNR sensor trans­duces a biochemical reaction into an electrical signal which can then be used to feedback on control processes. Within this project, we strive to combine our well-established SiNR sensing platform with molecular systems integrated in on-chip compartments that will play the role of molecular factories to gain further insight into their functioning and dynamical behavior.