In all European countries, devices are increasingly inserted in patients to relieve pain or improve function or for esthetic reasons. These implants can be foci for infection, which still represents one of the most serious and devastating complications, forcing patients back to surgery for infection control and/or implant replacement. In this context the development of new bioactive surfaces, aimed to reduce the high vulnerability of the interstitial milieu between implant and surrounding tissue, has a large impact on a growing medical problem, quality of patient life, and an opportunity for the production of new marketable technologies. In this interdisciplinary research project, we plan i) the synthesis of new silver coordination compounds, including complexes of Ag+ with antibiotics, ii) to test bacterial strains with and without biofilms for completeness, iii) to make systematic investigations on the mechanism of action of the compounds on the bacteria, using mutants as well as different screening methods such as agarose plates, confocal microscopy, micro- and nano-calorimetry and iv) in vivo studies of our promising candidates giving insights into real-life measurements, pharmaco-kinetics, and biocompatibility. To realize this project, we propose an interdisciplinary research team consisting of a chemist (synthesis and analysis), a material scientist (biomechanics, calorimetry), a microbiologist/infectious diseases specialist (in vitro and animal studies) and an orthopedic surgeon (in vitro).