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KRAB/KAP1 epigenetic regulation in the control of memory and emotional traits: from mice to humans
| Third-party funded project |
| Project title |
KRAB/KAP1 epigenetic regulation in the control of memory and emotional traits: from mice to humans |
| Principal Investigator(s) |
de Quervain, Dominique
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| Organisation / Research unit |
Bereich Psychiatrie (Klinik) / Kognitive Neurowissenschaften (de Quervain) |
| Project start |
01.10.2008 |
| Probable end |
30.09.2011 |
| Status |
Completed |
| Abstract |
This project aims at exploring the genetic bases of vulnerability to behavioral stress and stress-related disorders such as hyperanxiety, post-traumatic stress syndrome and depression. The four groups engaged in tackling this objective will capitalize on their recent discovery that a particular family of so-called epigenetic regulators of gene expression conditions susceptibility to behavioral stress and stress-induced cognitive defects in the mouse, and on their previous development of techniques to identify genetic factors related to emotional and non-emotional memory in humans. The study will combine molecular, genetic, behavioral and neuroimaging appraoches in a truly multidisciplinary atmosphere. The definition of genetic predictors of stress-induced pathologies will help design new approaches for the prevention and treatment of these pandemic diseases. |
| Financed by |
Swiss National Science Foundation (SNSF)
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24/04/2024
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