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Anti-IgE antibodies (Omalizumab) modfies the composition of the extracellular matrix by airway smooth muscle cells
| Third-party funded project |
| Project title |
Anti-IgE antibodies (Omalizumab) modfies the composition of the extracellular matrix by airway smooth muscle cells |
| Principal Investigator(s) |
Roth-Chiarello, Michael
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| Organisation / Research unit |
Departement Biomedizin / Pulmonary Cell Research (Roth/Tamm) |
| Project start |
01.11.2010 |
| Probable end |
30.04.2012 |
| Status |
Completed |
| Abstract |
Remodelling in asthma and COPD are today regarded as essential, pre-inflammation, events. Changes of the extracellular matrix are a central part of remodelling and it is unknown if IgE has any effect on this mechanism. This study investigates if IgE (which are enhanced in asthma) modify the composition of the extracellular matrix laid down by airway smooth muscle cells and if the inhibition of IgE can prevent or reduce remodelling of the lung. |
| Financed by |
Private Sector / Industry
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10/05/2024
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