|
|
Endothelial dysfunction, atherosclerosis and vascular insulin resistance- the multiregulatory role of T-cadherin
| Third-party funded project |
| Project title |
Endothelial dysfunction, atherosclerosis and vascular insulin resistance- the multiregulatory role of T-cadherin |
| Principal Investigator(s) |
Resink, Thérèse J.
|
| Organisation / Research unit |
Departement Biomedizin / Signal Transduction (Resink/Erne) |
| Project start |
01.01.2010 |
| Probable end |
30.06.2011 |
| Status |
Completed |
| Abstract |
Cardiovascular and metabolic diseases are an escalating public health issue worldwide due to increasingly aging populations and sedentary lifestyles and also the rising prevalence of obesity in children. Insulin resistance and endothelial dysfunction (ED) are frequently co-morbid states in cardiovascular and metabolic disorders. ED refers to a maladapted phenotype of vascular endothelial cell characterized by reduced bioavailability of nitric oxide (NO), a potent vasodilator. Insulin resistance is typically defined as decreased sensitivity or responsiveness to metabolic actions of insulin. However, diminished sensitivity or resistance to the actions of insulin in vascular endothelium also contributes importantly to the clinical phenotype of insulin-resistant states. A key vascular action of insulin is to stimulate production of NO from endothelium, which helps to couple metabolic and hemodynamic homeostasis under healthy conditions.
The goal of our project is to establish whether and how cell surface glycoprotein T-cadherin regulates signaling responses of endothelial cells to insulin and related functional downstream events including NO biosynthesis and angiogenesis. |
| Financed by |
Foundations and Associations
|
| |
|
|
MCSS v5.8 PRO. 0.453 sec, queries - 0.000 sec
©Universität Basel | Impressum
|  |
|
12/05/2024
Research Database / FORSCHUNGSDATENBANK
|
