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Neurovascular Coupling in Eyes of Glaucoma Patients
| Third-party funded project |
| Project title |
Neurovascular Coupling in Eyes of Glaucoma Patients |
| Principal Investigator(s) |
Orgül, Selim
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| Co-Investigator(s) |
Gugleta, Konstantin
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| Organisation / Research unit |
Bereich Spezialfächer (Klinik) / Ophthalmologie (Orgül) |
| Project start |
01.02.2008 |
| Probable end |
31.01.2011 |
| Status |
Completed |
| Abstract |
We hypothesize that glaucoma patients demonstrate an impaired retinal vascular response to the flicker stimulus, and that this disturbance is predictive of the progression of glaucomatous damage.
The response of a major temporal superior and inferior retinal artery and vein to a 60 seconds 12.5 Hz flicker light stimulation in 50 glaucoma patients, 50 ocular hypertensives and 50 controls (using the Retinal Vessel Analyzer) and to investigate how intraocular pressure relates to neurovascular coupling. In addition, 50 glaucoma patients and 50 ocular hypertension patients will be followed for 3 years for functional (visual field, automated perimetry with Octopus device) and morphological (retinal nerve fiber layer thickness, Optical Coherence Tomography Stratus OCT device) glaucomatous damage progression, in order to test the predictive power of the retinal vascular flicker response for glaucoma progression. |
| Financed by |
Private Sector / Industry
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15/05/2024
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