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Advances in understanding the role of stress in health and mental disorders: translational medicine approaches
| Third-party funded project |
| Project title |
Advances in understanding the role of stress in health and mental disorders: translational medicine approaches |
| Principal Investigator(s) |
Holsboer-Trachsler, Edith
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| Co-Investigator(s) |
Hatzinger, Martin
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| Organisation / Research unit |
Bereich Psychiatrie (Klinik) / Erwachsenenpsychiatrie (Lang) |
| Project start |
01.11.2009 |
| Probable end |
30.11.2009 |
| Status |
Completed |
| Abstract |
Stress, including severe psychological traumas, comprises one of the leading problems in today's society. Certainly, in South Africa, psychological trauma was rated one of the key challenges in an Essential National Health Research priority setting exercise. The adaptation to challenges from the environment and as well as to disturbances of the "milieu interne", is fundamentally linked to the activation of stress-responsive systems. The activation of these systems, i.e. the hypothalamus-pituitary-adrenal (HPA) system and the sympathoadrenergic system, is necessary for coping with stressors and for survival. However, the exaggerated or dysregulated activity of these systems not only renders human beings prone to psychiatric disease, but also to metabolic-endocrine disorders, heart disease and premature ageing. |
| Financed by |
Swiss National Science Foundation (SNSF)
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28/04/2024
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