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Acute Fatal Liver Toxicity under Erlotinib
JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)
 
ID 1198070
Author(s) Schacher-Kaufmann, Sabina; Pless, Miklos
Author(s) at UniBasel Pless, Miklos
Year 2010
Title Acute Fatal Liver Toxicity under Erlotinib
Journal Case Reports in Oncology
Volume 3
Number 2
Pages 182-188
Abstract We describe the case of a never-smoker who received second-line erlotinib as a treatment for his non-small cell lung cancer. Within one month, acute hepatic failure developed as well as a thrombotic-thrombocytopenic microangiopathy, with fatal outcome. In patients with non-small cell lung cancer, hepatic toxicity of erlotinib is a rare but severe complication; so far three fatal cases have been reported. Patients' liver function should be assessed before starting erlotinib and special care is recommended if pretreatment bilirubin is elevated.
Publisher Karger
ISSN/ISBN 1662-6575
edoc-URL http://edoc.unibas.ch/dok/A6008217
Full Text on edoc Available
Digital Object Identifier DOI 10.1159/000315366
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20740194
Document type (ISI) Journal Article
 
   

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