A 28-year-old man with headache, visual and aphasic speech disturbances
JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)
ID 1197780
Author(s) Frank, Stephan; Cordier, Dominik; Tolnay, Markus; Rosenblum, Marc K
Author(s) at UniBasel Tolnay, Markus
Year 2009
Title A 28-year-old man with headache, visual and aphasic speech disturbances
Journal Brain pathology
Volume 19
Number 1
Pages 163-6
Abstract A 28-year-old man presented with a short history of headache, visual and aphasic speech disturbances. MR scans revealed a large, partly cystic, contrast-enhancing lesion of the left temporal lobe that upon microscopic examination was diagnosed as pleomorphic xanthoastrocytoma (PXA) with anaplastic features (WHO grade III). Remarkably, this tumor featured an unusual gliovascular, rosette-like histoarchitecture, which had previously been hypothesized to possibly indicate a greater likelihood of PXA recurrence. Indeed, only 14 months later, the patient presented with a recurrent lesion, which contained the previous histology, but now also featured a distinct fibrosarcoma-like component replete with numerous osteoclast-type giant cells. In addition, whereas eosinophilic granular bodies were plentiful at the lesion's periphery, numerous CD34 - positive satellite cells were found in the adjacent non-infiltrated cortex. Regarding the origin of this recurrent tumor and in reflection of its composition of distinct PXA as well as sarcomatous components, the diagnosis of a pleomorphic xanthoastrosarcoma, to be conceptually considered as a gliosarcoma subtype, was made.To our knowledge, this is an unprecedented case of sarcomatous transformation of a PXA. Particular attention should be given to gliovascular pseudopapillary structures in PXAs, the presence of which may potentially herald a more aggressive clinical behavior.
ISSN/ISBN 1015-6305
edoc-URL http://edoc.unibas.ch/dok/A6007933
Full Text on edoc No
Digital Object Identifier DOI 10.1111/j.1750-3639.2008.00241.x
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/19076784
ISI-Number WOS:000261395200020
Document type (ISI) Letter

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