Addressing unmet clinical needs in the early diagnosis of sepsis
JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)
 
ID 1197584
Author(s) Schaub, Nora; Frei, Reno; Müller, Christian
Author(s) at UniBasel Müller, Christian
Year 2011
Title Addressing unmet clinical needs in the early diagnosis of sepsis
Journal Swiss Medical Weekly
Volume 141
Pages w13244
Keywords diagnosis, sepsis, blood culture, multiplex real-time PCR, calorimetry
Abstract The incidence of sepsis and the number of sepsis-related deaths are increasing, making sepsis the leading cause of death in critically ill patients in Europe and the U.S.A. Delayed recognition of sepsis and inappropriate initial antibiotic therapy are associated with an increase in mortality and morbidity. Rapid and accurate identification of sepsis and its causative organisms are a prerequisite for successful therapy. The current gold standard for the diagnosis of sepsis is culture of blood and other body fluids or tissues. However, even in severe sepsis, blood cultures (BC) yield the causative microorganism in only 20-40% of patients. Moreover, at least 24 hours are needed to get preliminary information about the potential organism. Therefore, novel laboratory methods for the diagnosis of sepsis, such as multiplex real-time polymerase chain reaction (PCR), matrix-assisted laser desorption ionisation (MALDI) time-of-flight (TOF) mass spectrometry (MS) (MALDI-TOF MS) and calorimetry, have been developed and evaluated.
Publisher EMH
ISSN/ISBN 1424-7860
edoc-URL http://edoc.unibas.ch/dok/A6007738
Full Text on edoc No
Digital Object Identifier DOI 10.4414/smw.2011.13244
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21769753
ISI-Number WOS:000293277700005
Document type (ISI) Journal Article, Review
 
   

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