Aplastic anemia : first-line treatment by immunosuppression and sibling marrow transplantation
JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)
 
ID 1197536
Author(s) Passweg, Jakob R; Marsh, Judith C W
Author(s) at UniBasel Passweg, Jakob R.
Year 2010
Title Aplastic anemia : first-line treatment by immunosuppression and sibling marrow transplantation
Journal Hematology : American Society of Hematology education program book
Volume 2010
Pages 36-42
Abstract Newly diagnosed aplastic anemia is a serious condition, with more than 75% (higher in young patients) becoming long-term survivors if diagnosed and treated appropriately. First-line treatment approaches include immunosuppressive treatment using the combination of antithymocyte globulin and cyclosporine A for patients without a sibling donor and HLA identical sibling transplant for patients younger than age 40 with a donor. Best transplant strategies have been defined and include conditioning with cyclophosphamide and antithymocyte globulin, marrow as a stem cell source, and graft-versus-host diease prophylaxis using cyclosporine A and methotrexate. It is against these standard treatment approaches that any therapeutic progress has to be measured.
Publisher American Society of Hematology
edoc-URL http://edoc.unibas.ch/dok/A6007691
Full Text on edoc No
Digital Object Identifier DOI 10.1182/asheducation-2010.1.36
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21239768
Document type (ISI) Journal Article, Review
 
   

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