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Randomisation to protect against selection bias in healthcare trials
Journal
Cochrane Database of Systematic Reviews
Volume
-
Number
4
Pages
MR000012
Keywords
Random Allocation, Selection Bias, Clinical Trials as Topic [methods; standards; statistics & numerical data], Controlled Clinical Trials as Topic [methods; standards; statistics & numerical data], Randomized Controlled Trials as Topic [methods; standards; statistics & numerical data], Treatment Outcome
Abstract
Randomised trials use the play of chance to assign participants to comparison groups. The unpredictability of the process, if not subverted, should prevent systematic differences between comparison groups (selection bias). Differences due to chance will still occur and these are minimised by randomising a sufficiently large number of people.
