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Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17
Journal
British journal of clinical pharmacology
Volume
69
Number
3
Pages
222-30
Abstract
Cytochrome P450 2C19 metabolizes many important drugs. In 2006, a variant allele (CYP2C19*17) associated with increased activity was discovered, but its likely clinical significance is controversial. Investigators disagree about the phenotype to be assigned to the two CYP2C19*17 genotypes. The aim of this study was to provide a critical summary, helpful to prescribers.
