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Stopping randomized trials early for benefit and estimation of treatment effects : systematic review and meta-regression analysis
JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)
 
ID 1197422
Author(s) Bassler, Dirk; Briel, Matthias; Montori, Victor M; Lane, Melanie; Glasziou, Paul; Zhou, Qi; Heels-Ansdell, Diane; Walter, Stephen D; Guyatt, Gordon H; STOPIT-2 Study Group; Flynn, David N; Elamin, Mohamed B; Murad, Mohammad Hassan; Abu Elnour, Nisrin O; Lampropulos, Julianna F; Sood, Amit; Mullan, Rebecca J; Erwin, Patricia J; Bankhead, Clare R; Perera, Rafael; Ruiz Culebro, Carolina; You, John J; Mulla, Sohail M; Kaur, Jagdeep; Nerenberg, Kara A; Schünemann, Holger; Cook, Deborah J; Lutz, Kristina; Ribic, Christine M; Vale, Noah; Malaga, German; Akl, Elie A; Ferreira-Gonzalez, Ignacio; Alonso-Coello, Pablo; Urrutia, Gerard; Kunz, Regina; Bucher, Heiner C; Nordmann, Alain J; Raatz, Heike; da Silva, Suzana Alves; Tuche, Fabio; Strahm, Brigitte; Djulbegovic, Benjamin; Adhikari, Neill K J; Mills, Edward J; Gwadry-Sridhar, Femida; Kirpalani, Haresh; Soares, Heloisa P; Karanicolas, Paul J; Burns, Karen E A; Vandvik, Per Olav; Coto-Yglesias, Fernando; Chrispim, Pedro Paulo M; Ramsay, Tim
Author(s) at UniBasel Nordmann, Alain J.
Bucher, Heiner
Briel, Matthias
Kunz, Regina
Year 2010
Title Stopping randomized trials early for benefit and estimation of treatment effects : systematic review and meta-regression analysis
Journal JAMA : the journal of the American Medical Association
Volume 303
Number 12
Pages 1180-7
Abstract Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome that precipitated early stopping.
Publisher American Medical Association
ISSN/ISBN 0098-7484
edoc-URL http://edoc.unibas.ch/dok/A6007577
Full Text on edoc No
Digital Object Identifier DOI 10.1001/jama.2010.310
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20332404
ISI-Number WOS:000275879600023
Document type (ISI) Journal Article, Review
 
   

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