Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks
The Effects of Antipsychotics on the Brain: What Have We Learnt from Structural Imaging of Schizophrenia? - A Systematic Review
JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)
ID
1197300
Author(s)
Smieskova, R.; Fusar-Poli, P.; Allen, P.; Bendfeldt, K.; Stieglitz, R. D.; Drewe, J.; Radue, E. W.; McGuire, P. K.; Riecher-Roessler, A.; Borgwardt, S. J.
The Effects of Antipsychotics on the Brain: What Have We Learnt from Structural Imaging of Schizophrenia? - A Systematic Review
Journal
Current Pharmaceutical Design
Volume
15
Number
22
Pages
2535-2549
Abstract
Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain abnormalities, we do not know to what extent such abnormalities reflect the effects of antipsychotic treatment on brain structure. We therefore systematically reviewed cross-sectional and follow-up structural brain imaging studies of patients with schizophrenia treated with antipsychotics. 30 magnetic resonance imaging (MRI) studies were identified, 24 of them being longitudinal and six cross-sectional structural imaging studies. In patients with schizophrenia treated with antipsychotics, reduced gray matter volume was described, particularly in the frontal and temporal lobes. Structural neuroimaging studies indicate that treatment with typical as well as atypical antipsychotics may affect regional gray matter (GM) volume. In particular, typical antipsychotics led to increased gray matter volume of the basal ganglia, while atypical antipsychotics reversed this effect after switching. Atypical antipsychotics, however, seem to have no effect on basal ganglia structure.
