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Investigating air pollution and atherosclerosis in humans : concepts and outlook
JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)
ID 1197219
Author(s) Künzli, Nino; Perez, Laura; von Klot, Stephanie; Baldassarre, Damiano; Bauer, Marcus; Basagana, Xavier; Breton, Carrie; Dratva, Julia; Elosua, Roberto; de Faire, Ulf; Fuks, Kateryna; de Groot, Eric; Marrugat, Jaume; Penell, Johanna; Seissler, Jochen; Peters, Annette; Hoffmann, Barbara
Author(s) at UniBasel Künzli, Nino
Dratva, Julia
Year 2011
Title Investigating air pollution and atherosclerosis in humans : concepts and outlook
Journal Progress in cardiovascular diseases
Volume 53
Number 5
Pages 334-43
Keywords Particulate matter, PM(2.5), Atherosclerosis, Cardiovascular diseases, Environment, Endothelial dysfunction, Air quality
Mesh terms Atherosclerosis, etiology; Biomarkers, analysis; Biomedical Research; Endpoint Determination; Evidence-Based Medicine; Humans; Inhalation Exposure; Particulate Matter, adverse effects; Public Health; Research Design; Risk Assessment; Risk Factors
Abstract Although ambient particulate matter contributes to atherosclerosis in animal models, its role in atherogenesis in humans needs to be established. This article discusses concepts, study design, and choice of health outcomes to efficiently investigate the atherogenic role of ambient air pollution, with an emphasis on early preclinical biomarkers of atherosclerosis that are unaffected by short-term exposure to air pollution (eg, carotid intima-media thickness [CIMT] and functional performance of the vessel). Air pollution studies using these end points are summarized. The CIMT is currently the most frequently used outcome in this field (6 studies). The continuous nature of CIMT, the lack of short-term variation, its relationship to atherosclerotic changes in the artery wall, its predictive value for coronary heart disease, and the noninvasiveness of the assessment make it a useful candidate for cross-sectional and longitudinal studies investigating the role of air pollution in atherogenesis.
Publisher Grune & Stratton
ISSN/ISBN 0033-0620
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.pcad.2010.12.006
PubMed ID
ISI-Number WOS:000288922000002
Document type (ISI) Journal Article, Review

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