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Allograft inflammatory factor-1: a pathogenetic factor for vasculitic neuropathy
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1196967
Author(s) Broglio, Laura; Erne, Beat; Tolnay, Markus; Schaeren-Wiemers, Nicole; Fuhr, Peter; Steck, Andreas J; Renaud, Susanne
Author(s) at UniBasel Steck, Andreas
Fuhr, Peter
Renaud, Susanne
Tolnay, Markus
Schaeren-Wiemers, Nicole
Year 2008
Title Allograft inflammatory factor-1: a pathogenetic factor for vasculitic neuropathy
Journal Muscle & nerve
Volume 38
Number 4
Pages / Article-Number 1272-9
Keywords AIF-1, CIDP, nerve inflammation, vascular smooth muscle cells, vasculitic neuropathy
Abstract

Allograft inflammatory factor-1 (AIF-1) is a cytokine that plays a major role in the immune response and proliferative vasculopathy that occur during chronic allograft rejection. The purpose of this study was to characterize the cellular expression pattern and pathogenetic role of AIF-1 in nerve biopsies from patients with vasculitic neuropathy. We performed immunohistochemistry in human nerve biopsies of 10 patients with vasculitic neuropathies (VASs), 6 with chronic inflammatory demyelinating polyneuropathies (CIDPs), 5 with noninflammatory axonal neuropathies (NIANs), and 3 control nerves (CNs). In the CIDP and VAS nerves, AIF-1 expression was higher than in CN and NIAN nerves (P < 0.05). AIF-1 was increased in the arterial walls of VAS compared with CIDP nerves (P < 0.05). Vascular smooth muscle cells in vasculitic nerve express AIF-1 at a higher level compared with CIDP and NIAN. AIF-1 plays a role in inflammatory nerve disease and vascular smooth muscle cell proliferation and may be a new molecular target for treatment.

Publisher John Wiley
ISSN/ISBN 0148-639X
edoc-URL http://edoc.unibas.ch/dok/A6007127
Full Text on edoc No
Digital Object Identifier DOI 10.1002/mus.21033
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/18816612
ISI-Number WOS:000259843700008
Document type (ISI) Journal Article
 
   

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