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Assessing the value of CAN-gene mutations using MALDI-TOF MS
Journal
Journal of cancer research and clinical oncology
Volume
137
Number
8
Pages / Article-Number
1239-44
Keywords
Breast cancer, CAN-genes, MALDI-TOF MS, Multiplex assay
Abstract
To identify cancer-linked genes, Sjöblom et al. and Wood et al. performed a genome-wide mutation screening in human breast and colorectal cancers. 140 CAN-genes were found in breast cancer, which in turn contained overall 334 mutations. These mutations could prove useful for diagnostic and therapeutic purposes.