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Neuroanatomical abnormalities that predate the onset of psychosis : a multicenter study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
1196807
Author(s)
Mechelli, Andrea; Riecher-Rössler, Anita; Meisenzahl, Eva M; Tognin, Stefania; Wood, Stephen J; Borgwardt, Stefan J; Koutsouleris, Nikolaos; Yung, Alison R; Stone, James M; Phillips, Lisa J; McGorry, Patrick D; Valli, Isabel; Velakoulis, Dennis; Woolley, James; Pantelis, Christos; McGuire, Philip
Neuroanatomical abnormalities that predate the onset of psychosis : a multicenter study
Journal
Archives of general psychiatry
Volume
68
Number
5
Pages / Article-Number
489-95
Abstract
People experiencing possible prodromal symptoms of psychosis have a very high risk of developing the disorder, but it is not possible to predict, on the basis of their presenting clinical features, which individuals will subsequently become psychotic. Recent neuroimaging studies suggest that there are volumetric differences between individuals at ultra-high risk (UHR) for psychosis who later develop psychotic disorder and those who do not. However, the samples examined to date have been small, and the findings have been inconsistent.