Assessment of magnetization transfer effects in myocardial tissue using balanced steady-state free precession (bSSFP) cine MRI
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1196587
Author(s) Weber, Oliver M; Speier, Peter; Scheffler, Klaus; Bieri, Oliver
Author(s) at UniBasel Scheffler, Klaus
Year 2009
Title Assessment of magnetization transfer effects in myocardial tissue using balanced steady-state free precession (bSSFP) cine MRI
Journal Magnetic resonance in medicine : MRM : an official journal of the International Society for Magnetic Resonance in Medicine
Volume 62
Number 3
Pages / Article-Number 699-705
Keywords magnetization transfer, balanced SSFP, cardiac MRI, myocardial infarct
Abstract Magnetization transfer imaging (MTI) by means of MRI exploits the mobility of water molecules in tissue and offers an alternative contrast mechanism beyond the more commonly used mechanisms based on relaxation times. A cardiac MTI method was implemented on a commercially available 1.5 T MR imager. It is based on the acquisition of two sets of cardiac-triggered cine balanced steady-state free precession (bSSFP) images with different levels of RF power deposition. Reduction of RF power was achieved by lengthening the RF excitation pulses of a cine bSSFP sequence from 0.24 ms to 1.7 ms, while keeping the flip angle constant. Normal volunteers and patients with acute myocardial infarcts were imaged in short and long axis views. Normal myocardium showed an MT ratio (MTR) of 33.0 +/- 3.3%. In acute myocardial infarct, MTR was reduced to 24.5 +/- 9.2% (P < 0.04), most likely caused by an increase in water content due to edema. The method thus allows detection of acute myocardial infarct without the administration of contrast agents.
Publisher Wiley-Liss
ISSN/ISBN 0740-3194
edoc-URL http://edoc.unibas.ch/dok/A6006752
Full Text on edoc No
Digital Object Identifier DOI 10.1002/mrm.22053
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/19572387
ISI-Number WOS:000269404900017
Document type (ISI) Journal Article
 
   

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