AMACR expression in colorectal cancer is associated with left-sided tumor localization
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 1196472
Author(s) Marx, Andreas; Simon, Philipp; Simon, Ronald; Mirlacher, Martina; Izbicki, Jakob R; Yekebas, Emre; Kaifi, Jussuf T; Terracciano, Luigi; Sauter, Guido
Author(s) at UniBasel Terracciano, Luigi M.
Year 2008
Title AMACR expression in colorectal cancer is associated with left-sided tumor localization
Journal Virchows Archiv
Volume 453
Number 3
Pages / Article-Number 243-8
Keywords AMACR, colorectal cancer
Abstract Alpha-methylacyl-CoA racemase (AMACR) is an enzyme playing an important role in the beta-oxidation of branched-chain fatty acids and fatty acid derivatives. Altered expression levels of AMACR have been described in various cancers including colorectal cancer (CRC). To determine the potential prognostic impact of AMACR expression, we analyzed 1,315 CRC on a tissue microarray (TMA) by immunohistochemistry (IHC). Clinical follow-up data were available from all cancer patients. Positive AMACR staining was observed in 1,074 (81.7%) of the 1,315 cases including 276 cancers with weak (21.0%) and 798 cancers with strong staining (60.7%). AMACR IHC was significantly associated with tumor grade, stage, non-mucinous phenotype, and left-sided tumor localization (p < 0.0001 each). AMACR positivity was observed in 65.8% of cancers from the right-sided colon, in 73.2% of cancers from the colon transversum, in 81.1% of cancers from the colon descendens, and in 88.9% of the distal left-sided cancers (sigma and rectum; p < 0.0001). However, AMACR staining results were unrelated to clinical outcome. It is concluded that AMACR cannot serve as a prognostic marker in CRC. We hypothesize that the association of AMACR expression with tumor localization may be related to differences in the metabolism/exposure to fatty acids occurring along the colon.
Publisher Springer
ISSN/ISBN 0945-6317
Full Text on edoc No
Digital Object Identifier DOI 10.1007/s00428-008-0646-1
PubMed ID
ISI-Number WOS:000259188400003
Document type (ISI) Article

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