Androgen and gonadotropin patterns differ in HIV-1-infected men who develop lipoatrophy during antiretroviral therapy : a case-control study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1196466
Author(s) Wunder, D M; Fux, C A; Bersinger, N A; Mueller, N J; Hirschel, B; Cavassini, M; Elzi, L; Schmid, P; Bernasconi, E; Mueller, B; Furrer, H; Swiss HIV Cohort Study
Author(s) at UniBasel Elzi, Luigia
Year 2008
Title Androgen and gonadotropin patterns differ in HIV-1-infected men who develop lipoatrophy during antiretroviral therapy : a case-control study
Journal HIV medicine
Volume 9
Number 6
Pages / Article-Number 427-32
Keywords antiretroviral therapy, dehydroepiandrosterone, follicle-stimulating hormone, free testosterone, HIV, lipoatrophy, lipodystrophy, luteinizing hormone
Abstract OBJECTIVES: We compared androgen and gonadotropin values in HIV-infected men who did and did not develop lipoatrophy on combination antiretroviral therapy (cART). METHODS: From a population of 136 treatment-naïve male Caucasians under successful zidovudine/lamivudine-based cART, the 10 patients developing lipoatrophy (cases) were compared with 87 randomly chosen controls. Plasma levels of free testosterone (fT), dehydroepiandrosterone (DHEA), follicle-stimulating hormone and luteinizing hormone (LH) were measured at baseline and after 2 years of cART. RESULTS: At baseline, 60% of the cases and 71% of the controls showed abnormally low fT values. LH levels were normal or low in 67 and 94% of the patients, respectively, indicating a disturbance of the hypothalamic-pituitary-gonadal axis. fT levels did not significantly change after 2 years of cART. Cases showed a significant increase in LH levels, while controls showed a significant increase in DHEA levels. In a multivariate logistic regression model, lipoatrophy was associated with higher baseline DHEA levels (P=0.04), an increase in LH levels during cART (P=0.001), a lower body mass index and greater age. CONCLUSIONS: Hypogonadism is present in the majority of HIV-infected patients. The development of cART-related lipoatrophy is associated with an increase in LH and a lack of increase in DHEA levels.
Publisher Blackwell
ISSN/ISBN 1464-2662
edoc-URL http://edoc.unibas.ch/dok/A6006634
Full Text on edoc No
Digital Object Identifier DOI 10.1111/j.1468-1293.2008.00578.x
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/18459947
ISI-Number WOS:000257484000010
Document type (ISI) Journal Article
 
   

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