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Computed high concentrations of low-density lipoprotein correlate with plaque locations in human coronary arteries
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1196353
Author(s) Olgac, Ufuk; Knight, Joseph; Poulikakos, Dimos; Saur, Stefan C; Alkadhi, Hatem; Desbiolles, Lotus M; Cattin, Philippe C; Kurtcuoglu, Vartan
Author(s) at UniBasel Cattin, Philippe Claude
Year 2011
Title Computed high concentrations of low-density lipoprotein correlate with plaque locations in human coronary arteries
Journal Journal of biomechanics
Volume 44
Number 13
Pages / Article-Number 2466-71
Keywords LDL transport, Patient-specific simulations, Atherosclerosis, Computational fluid dynamics, Computed tomography
Abstract Subendothelial accumulation of low-density lipoprotein (LDL) in arterial walls is an initiator of atherosclerotic plaque formation. We report here on the correlation between healthy state subendothelial LDL concentration distribution and sites of subsequent plaque formation in coronary arteries of patients with coronary artery disease (CAD). We acquired left (LCA) and right coronary artery (RCA) and atherosclerotic plaque geometries of 60 patients with CAD using dual-source computed tomography angiography. After virtually removing all plaques to obtain an approximation of the arteries' healthy state, we calculated LDL concentration in the artery walls as a function of local lumen-side shear stress. We found that maximum subendothelial LDL concentrations at plaque locations were, on average, 45% (RCA) and 187% (LCA) higher than the respective average subendothelial concentration. Our results demonstrate that locally elevated subendothelial LDL concentration correlates with subsequent plaque formation at the same location.
Publisher Elsevier Science
ISSN/ISBN 0021-9290
edoc-URL http://edoc.unibas.ch/dok/A6006524
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.jbiomech.2011.06.022
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21723556
ISI-Number WOS:000294934200018
Document type (ISI) Journal Article
 
   

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