An overview of biomarkers for the ovarian cancer diagnosis
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1196317
Author(s) Zhang, Bei; Cai, Feng Feng; Zhong, Xiao Yan
Author(s) at UniBasel Zhong, Xiao Yan
Year 2011
Title An overview of biomarkers for the ovarian cancer diagnosis
Journal European journal of obstetrics, gynecology, and reproductive biology
Volume 158
Number 2
Pages / Article-Number 119-23
Keywords Biomarker, Proteomics, Ovarian cancer, Microrna, Metabolite
Abstract

Even though there are a lot of options in treating gynecological malignancies, ovarian cancer still remains a leading cause of death. Diagnosis at an early stage is the most important determinant of survival. Current diagnostic tools applied at clinics have had very limited success in early detection. Discovery of new diagnostic biomarkers/panels for early diagnosis of ovarian cancer is one of the main challenges of modern medicine. With the progress of techniques in genomics and proteomics, numerous molecular biomarkers/panels were identified and showed promise for ovarian cancer diagnosis, but still need further validation. This article summarizes various types of markers investigated by different strategies/technologies for the ovarian cancer diagnosis at present, including gene-, protein-based and emerging ovarian cancer indicators (such as microRNA-, metabolite-based). Before biomarker tests are translated for routine use, more researches, such as retrospective and prospective clinical trials, are needed to evaluate the overall clinical utility of the tests.

Publisher Elsevier
ISSN/ISBN 0301-2115
edoc-URL http://edoc.unibas.ch/dok/A6006488
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.ejogrb.2011.04.023
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21632171
ISI-Number WOS:000296301900001
Document type (ISI) Journal Article, Review
 
   

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