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Risk factors of new-onset asthma in adults: a population-based international cohort study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 1196147
Author(s) Antó, J. M.; Sunyer, J.; Basagaña, X.; Garcia-Esteban, R.; Cerveri, I.; de Marco, R.; Heinrich, J.; Janson, C.; Jarvis, D.; Kogevinas, M.; Kuenzli, N.; Leynaert, B.; Svanes, C.; Wjst, M.; Gislason, T.; Burney, P.
Author(s) at UniBasel Künzli, Nino
Year 2010
Title Risk factors of new-onset asthma in adults: a population-based international cohort study
Journal Allergy
Volume 65
Number 8
Pages / Article-Number 1021-30
Mesh terms Adult; Age of Onset; Animals; Asthma, etiology; Bronchial Hyperreactivity, epidemiology; Cats, immunology; Cohort Studies; Europe, epidemiology; Female; Health Surveys; Humans; Hypersensitivity, Immediate, etiology; Incidence; Longitudinal Studies; Male; Population Surveillance, methods; Respiratory Function Tests; Respiratory Tract Infections, epidemiology; Risk Factors; Young Adult
Abstract The occurrence of new-onset asthma during adulthood is common, but there is insufficient understanding of its determinants including the role of atopy. To assess the risk factors for the development of new-onset asthma in middle-aged adults and to compare them according to atopy. A longitudinal analysis of 9175 young adults who participated in two surveys of the European Community Respiratory Health Survey (ECRHS) conducted 9 years apart. We observed 179 cases of new-onset asthma among 4588 participants who were free of asthma and reported at the beginning of the follow-up that they had never had asthma (4.5 per 1000 person-years). In a logistic regression, the following risk factors were found to increase the risk of new-onset asthma: female gender (OR: 1.97; 95% confidence interval (CI): 1.38, 2.81), bronchial hyperresponsiveness (3.25; 2.19, 4.83), atopy (1.55; 1.08, 2.21), FEV(1) < 100 % predicted (1.87; 1.34, 2.62), nasal allergy (1.98;1.39,2.84) and maternal asthma (1.91; 1.13; 3.21). Obesity, respiratory infections in early life and high-risk occupations increased the risk of new-onset asthma although we had limited power to confirm their role. Among the atopics, total IgE and sensitization to cat were independently related to the risk of new-onset asthma. The proportion of new-onset asthma attributable to atopy varied from 12% to 21%. Adults reporting that they had never had asthma were at a substantial risk of new-onset asthma as a result of multiple independent risk factors including lung function. Atopy explains a small proportion of new-onset adult asthma.
Publisher Munksgaard
ISSN/ISBN 0105-4538 ; 1398-9995
Full Text on edoc No
Digital Object Identifier DOI 10.1111/j.1398-9995.2009.02301.x
PubMed ID
ISI-Number WOS:000279437600010
Document type (ISI) Journal Article

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